Toxiciting Issues

Toxiciting Issues


Here are two websites with information about aluminum and Mitochondria:

Aluminum and Vaccine Ingredients: What Do We Know? What Don’t We Know?
by Lawrence B. Palevsky, MD, FAAP

Is Aluminum the New Thimerosal?
By Robert W. Sears Issue 146, January/February 2008

Here is a published article on the same topic:

Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity
Mailloux R, Lemire J, Appanna V.
Cell Physiol Biochem. 2007;20(5):627-38.

Mitochondrial dysfunction is the cause of a variety of pathologies associated with high energy-requiring tissues like the brain and muscles. Here we show that aluminum (Al) perturbs oxidative-ATP production in human hepatocytes (HepG2 cells). This Al-induced mitochondrial dysfunction promotes enhanced lipogenesis and the accumulation of the very low density lipoprotein (VLDL). Al-stressed HepG2 cells secreted more cholesterol, lipids and proteins than control cells. The level of apolipoprotein B-100 (ApoB-100) was markedly increased in the culture medium of the cells exposed to Al. (13)C-NMR and HPLC studies revealed a metabolic profile favouring lipid production and lowered ATP synthesis in Al-treated cells. Electrophoretic and immunoblot analyses pointed to increased activities and expression of lipogenic enzymes such as glycerol 3-phosphate dehydrogenase (G3PDH), acetyl CoA carboxylase (ACC) and ATP-citrate lyase (CL) in the hepatocytes exposed to Al, and a sharp diminution of enzymes mediating oxidative phosphorylation. D-Fructose elicited the maximal secretion of VLDL in the Al-challenged cells. These results suggest that the Al-evoked metabolic shift favours the accumulation of lipids at the expense of oxidative energy production in hepatocytes. Copyright (c) 2007 S. Karger AG, Basel.

PMID: 17762189

Toxicity Issues

How you can check for lead in toys in your home

Lead Toxicity

Christine and Erik Johnson of Minneapolis were thrust into the role of detectives when they learned in November 2006 that their 9-month-old son, Coen, had a blood lead level about five times the national average for children under 5. His 2-year-old sister, Nora, had a lead level that was almost triple the average. Read more…

Toxic Baby Formula

Liquid infant formula from the top manufacturers is sold in cans lined with a toxic chemical linked to reproductive disorders and neurobehavioral problems in laboratory animals, according to an investigation by Environmental Working Group (EWG).

Dangerous levels of arsenic in 10% of rice

By Charles Clover, Environment Editor
Last Updated: 7:01pm BST 29/08/2007
A third of baby rice tested by the Food Standards Agency contains high levels of arsenic, one of the worst cancer causing chemicals, a leading expert has said.

Read more…

“Silver” dental fillings contain toxic mercury

The article below, “End of Mercury Fillings,” is by George G. Brown, national counsel for Consumers for Dental Choice; published on December 31, 2008.

The biggest change in the history of American dentistry is about to occur. The United States Food and Drug Administration (FDA) is on the verge of limiting the use of dentistry’s 19th-century foundation-stone, amalgam fillings. Though promoted as “silver fillings,” this material is 50 percent mercury and only 25 percent silver.

Mercury is, of course, highly toxic; it can cause permanent harm to a fetus, to a child’s developing brain or an adult’s kidneys. The World Health Organization says no safe level of mercury exists. Unlike lead, whose risk becomes acute when the child licks it, mercury is notoriously volatile (it is the only metal in liquid form at room temperature), so its vapors alone can cause neurological or fetal damage. The U.S. Centers for Disease Control warns that mercury from amalgam is “a major source” of mercury exposure to our bodies. In dentistry’s early days, no alternative existed, except expensive gold. That excuse is over. Composite, a white resin-like material, is interchangeable with mercury amalgam, albeit it takes a few moments longer to implant. That means, for upper-middle-class adults who go to modern dentists, composite is the norm. For children, working Americans, soldiers and sailors, prisoners and others receiving assembly-line dentistry, however, it is still mercury, mercury, mercury. Emmitt Carlton, a Washington lawyer testifying on behalf of the NAACP before the U.S. House Subcommittee on Wellness and Human Rights in 2003, summarized American dentistry as providing “choice for the rich, mercury for the poor.”

Dental mercury is an environmental hazard. A report by the Mercury Policy Project shows that dental offices are the largest source of mercury in the nation’s wastewater. Hence, dentistry puts an unnecessary burden on taxpayers to clean it up. Prudently, the Corzine administration ordered all dentists, effective Oct. 1, 2007, to install and maintain amalgam separators to catch mercury before it enters New Jersey’s water supply.

This rule, written by the state Department of Environmental Protection, took another step to reduce pollution, directing dentists, “where appropriate,” to use alternatives to amalgam.

Many dentists don’t need to be encouraged to quit; to their credit, between one-third and one-half of U.S. dentists have stopped using amalgam. With the pollution, the health controversy and the social-justice disparities, the question isn’t why so many dentists have switched — it’s why so many hang onto this anachronism.

Taking an active interest in the issue is Sen. Ronald Rice, D-Newark, sponsor of a bill directing the state Department of Health and Senior Services to investigate mercury use in dental fillings and to study its health and occupational effects. Also, New Jersey Attorney General Anne Milgram led the states, with New Jersey as the lead plaintiff, to compel the Bush administration to enforce the laws against mercury pollution.

To protect their babies, pregnant women are warned not to get any unnecessary exposure to mercury, such as to avoid eating tuna. Several years ago, a report by the U.S. Environmental Protection Agency showed that one in eight women of childbearing age is already so mercury toxic she is at risk of having a brain-damaged baby. Imagine if a dentist, instead of using the misnomer “silver fillings,” told a pregnant patient to prepare to receive “mercury fillings.” It is safe to assume she would vacate the dental chair immediately.

So mired in mercury is New Jersey that it seeks to ship it out. The state is battling obstacles to send tons of mercury sitting in Somerset County to Nevada. Congress has, however, closed off the option of shipping New Jersey’s mercury overseas; the Mercury Export Ban Act of 2008 bans mercury exports. The law’s lead sponsor: Sen., now president-elect, Barack Obama. Such strong action by our next president forecasts an administration that may be tough on mercury products and mercury users.

Mercury-free dentistry is more than a health and environment issue — it is a workplace safety issue. Largely female and of childbearing age, dental workers are the very persons who should be the most vigilant to avoid exposure to mercury vapors — which happens, sadly, each time a dental worker opens the amalgam capsule.

In New Jersey, private-sector workplace safety is enforced by the U.S. Occupational Health Safety Administration (OSHA), while the public sector workplace is handled by the New Jersey Public Employees Occupational Safety Health program (“PEOSH”).

Fortunately, New Jersey PEOSH is ahead of the nation in the arena of protecting employees from mercury; its standard is for employers to “substitute safer chemicals” for mercury. But PEOSH has not acted on our request to apply its standard to dental clinics at UMDNJ and the state prisons, choosing, to date, not even to issue an alert (an advisory about the law).

The contrast between the Corzine administration’s vigorous environmental policy against mercury and its indifference toward workplace mercury is startling. In its environmental policies, New Jersey is positioned to be the cutting-edge state in the transition to mercury-free dentistry. But unwillingness to enforce its own workplace safety policies means New Jersey is putting young female workers at risk not only for themselves, but for their present and future babies.

Charles G. Brown is national counsel for Consumers for Dental Choice.

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